Evaluation of Factors Leading to Anion Gap Re-Opening in Adults with Diabetic Ketoacidosis
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چکیده
Methods: This study was a single-centered, retrospective chart review. The population included all adult patients admitted to a large academic medical center from December 2014 to November 2015 from the emergency department to an adult inpatient floor with a primary diagnosis of diabetic ketoacidosis. The primary efficacy endpoint included gap closure of 12 or less. The primary safety endpoint included gap re-opening, defined as an anion gap >15.
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INTRODUCTION Acute metabolic acidosis of non-renal origin is usually a result of either lactic or ketoacidosis, both of which are associated with a high anion gap. There is increasing recognition, however, of a group of acidotic patients who have a large anion gap that is not explained by either keto- or lactic acidosis nor, in most cases, is inappropriate fluid resuscitation or ingestion of ex...
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تاریخ انتشار 2017